Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer ’ s Disease

Abstract

Alzheimer’s Disease (AD) is a disease of synaptic dysfunction that ultimately proceeds to neuronal death. There is a wealth of evidence that indicates the final common mediator of this neurotoxic process is the formation and actions on synaptotoxic b-amyloid (Ab). The premise in this review is that synaptic dysfunction may also be an initiating factor in… (More)

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