Phosphodiesterase III inhibitors for heart failure.

  title={Phosphodiesterase III inhibitors for heart failure.},
  author={Emmanuel Amsallem and Charoutiun Kasparian and G Haddour and Jean Pierre Boissel and Patrice Nony},
  journal={The Cochrane database of systematic reviews},
BACKGROUND In the treatment of chronic heart failure, vasodilating agents, ACE inhibitors and beta-blockers have shown an increase of life expectancy. Another strategy is to increase the inotropic state of the myocardium : phosphodiesterase inhibitors (PDIs) act by increasing intra-cellular cyclic AMP, thereby increasing the concentration of intracellular calcium, and lead to a positive inotropic effect. OBJECTIVES This overview on summarised data aims to review the data from all randomised… CONTINUE READING
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