Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

  title={Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid},
  author={Takakuni Maki and Yoko Okamoto and Roxana O. Carare and Yoshiki Hase and Yorito Hattori and Cheryl A. Hawkes and Satoshi Saito and Yumi Yamamoto and Yasukazu Terasaki and Hatsue Ishibashi-Ueda and A. Hisanori Taguchi and Ryosuke Takahashi and Taihei Miyakawa and Raj N Kalaria and Eng H. Lo and Ken Arai and Masafumi Ihara},
  booktitle={Annals of clinical and translational neurology},
OBJECTIVE Brain amyloidosis is a key feature of Alzheimer's disease (AD). It also incorporates cerebrovascular amyloid β (Aβ) in the form of cerebral amyloid angiopathy (CAA) involving neurovascular dysfunction. We have recently shown by retrospective analysis that patients with mild cognitive impairment receiving a vasoactive drug cilostazol, a selective inhibitor of phosphodiesterase (PDE) III, exhibit significantly reduced cognitive decline. Here, we tested whether cilostazol protects… CONTINUE READING
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