Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.

@article{Xiang2005Phosphodiesterase4I,
  title={Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.},
  author={Yang Xiang and Fabio Naro and Maria Zoudilova and S. L. Catherine Jin and M. P{\'e}rez-D{\'i}az Conti and Brian K. Kobilka},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 3},
  pages={909-14}
}
beta adrenoceptor (betaAR) signaling is finely regulated to mediate the sympathetic nervous system control of cardiovascular function. In neonatal cardiac myocytes, beta1AR activates the conventional Gs/cAMP pathway, whereas beta2AR sequentially activates both the Gs and Gi pathways to regulate the myocyte contraction rate. Here, we show that phosphodiesterase 4D (PDE4D) selectively impacts signaling by beta2AR in neonatal cardiac myocytes, while having little or no effect on beta1AR signaling… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…