Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages

@inproceedings{Yang2017Phosphodiesterase4N,
  title={Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages},
  author={Jing-Xing Yang and Kou-Chou Hsieh and Yi-Ling Chen and Chien-Kuo Lee and Marco Conti and Tsung-Hsien Chuang and Chin-pyng Wu and S.-L. Catherine Jin},
  booktitle={Scientific reports},
  year={2017}
}
Activation of TLR4 by lipopolysaccharide (LPS) induces both pro-inflammatory and anti-inflammatory cytokine production in macrophages. Type 4 phosphodiesterases (PDE4) are key cAMP-hydrolyzing enzymes, and PDE4 inhibitors are considered as immunosuppressors to various inflammatory responses. We demonstrate here that PDE4 inhibitors enhance the anti… CONTINUE READING