Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.

@article{Leroy2011Phosphodiesterase4I,
  title={Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.},
  author={J{\'e}r{\^o}me Leroy and Wito Richter and Delphine Mika and Liliana R V Castro and Aniella Abi-Gerges and Moses Xie and Colleen Scheitrum and Florence Lefebvre and Julia Schittl and Philippe Mateo and Ruth E. Westenbroek and William A. Catterall and F. Charpentier and M. P{\'e}rez-D{\'i}az Conti and Rodolphe Fischmeister and Gr{\'e}goire Vandecasteele},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 7},
  pages={2651-61}
}
β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca²⁺-induced Ca²⁺ release via phosphorylation of L-type Ca²⁺ channels (LTCCs) and ryanodine receptor 2. Multiple cyclic nucleotide phosphodiesterases (PDEs) regulate local cAMP concentration in cardiomyocytes, with PDE4 being predominant for the control of β-AR-dependent cAMP signals. Three genes encoding PDE4 are expressed in mouse heart: Pde4a, Pde4b, and Pde4d. Here we… CONTINUE READING

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