Phosphodiesterase 4 inhibitors reduce human dendritic cell inflammatory cytokine production and Th1-polarizing capacity.

Abstract

Inhibitors of cAMP-specific phosphodiesterase (PDE) 4 have been shown to inhibit inflammatory mediator release and T cell proliferation, and are considered candidate therapies for T(h)1-mediated diseases. However, little is known about how PDE4 inhibitors influence dendritic cells (DC), the cells responsible for the priming of naive T(h) cells. Therefore… (More)

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Cite this paper

@article{Heystek2003Phosphodiesterase4I, title={Phosphodiesterase 4 inhibitors reduce human dendritic cell inflammatory cytokine production and Th1-polarizing capacity.}, author={Heleen C. Heystek and A. M. Thierry and Patricia Soulard and Corinne Moulon}, journal={International immunology}, year={2003}, volume={15 7}, pages={827-35} }