Phosphodiesterase-4 inhibition reduces proteolysis and atrogenes expression in rat skeletal muscles.

Abstract

Phosphodiesterase (PDE) inhibition reduces skeletal muscle atrophy, but the underlying molecular mechanism remains unclear. We used microdialysis to investigate the effects of different PDE inhibitors on interstitial tyrosine concentration as well as proteolytic activity and atrogenes expression in isolated rat muscle. Rolipram, a PDE-4-selective inhibitor… (More)
DOI: 10.1002/mus.22066

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@article{Lira2011Phosphodiesterase4IR, title={Phosphodiesterase-4 inhibition reduces proteolysis and atrogenes expression in rat skeletal muscles.}, author={Eduardo C Lira and Dawit Albieiro Pinheiro Gonçalves and Lucas T. Parreiras-e-Silva and Neusa Maria Zanon and Isis do Carmo Kettelhut and Luiz Carlos Carvalho Navegantes}, journal={Muscle & nerve}, year={2011}, volume={44 3}, pages={371-81} }