Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats.

@article{Visser2012Phosphodiesterase4I,
  title={Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats.},
  author={Yvonne P de Visser and Frans J Walther and El Houari Laghmani and Paul Steendijk and Maaike Middeldorp and Arnoud van der Laarse and Gerry T. M. Wagenaar},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2012},
  volume={302 1},
  pages={L56-67}
}
Phosphodiesterase (PDE) 4 inhibitors are potent anti-inflammatory drugs with antihypertensive properties, and their therapeutic role in bronchopulmonary dysplasia (BPD) is still controversial. We studied the role of PDE4 inhibition with piclamilast on normal lung development and its therapeutic value on pulmonary hypertension (PH) and right ventricular hypertrophy (RVH) in neonatal rats with hyperoxia-induced lung injury, a valuable model for premature infants with severe BPD. The… CONTINUE READING
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