Phosphodiesterase 4 and its inhibitors in inflammatory diseases.

  title={Phosphodiesterase 4 and its inhibitors in inflammatory diseases.},
  author={S. L. Catherine Jin and Shiau-Li Ding and Shih-Chang Lin},
  journal={Chang Gung medical journal},
  volume={35 3},
Type 4 cyclic nucleotide phosphodiesterases (PDE4) are a family of low km 3',5'-cyclic adenosine monophosphate (cAMP)-specific phosphodiesterases including at least 20 isozymes encoded by four genes (PDE4A, PDE4B, PDE4C, and PDE4D) in mammals. Each PDE4 gene plays a special, nonredundant role in the control of cell function even though the four subfamilies… CONTINUE READING