Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane.

@article{Crilly2011Phosphodiesterase4,
  title={Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane.},
  author={Anne Crilly and Susan E. Robertson and James H. Reilly and J. Alastair Gracie and Wen-Qi Lai and Bernard P L Leung and Paul F Life and Iain B. Mcinnes},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 6},
  pages={1130-7}
}
BACKGROUND The cAMP-metabolising enzyme, phosphodiesterase 4 (PDE4), has been implicated in a number of immune responses, including tumour necrosis factor α (TNFα) production. To date, few data have directly addressed whether synovial cytokine and chemokine production is modified by PDE4. OBJECTIVE Using specific PDE4 inhibitors, roflumilast plus two… CONTINUE READING