Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase

Abstract

Phosphodiesterase 3 (PDE3) exists in two isoforms (PDE3A and PDE3B) and is known to act as cGMP-inhibited cAMP-degrading PDE. Therefore, PDE3 may likely be involved in the interaction between the two second messenger pathways. NO-sensitive guanylyl cyclase (NO-GC) is the most important cytosolic generator of cGMP. Here, we investigated the effect of NO-GC… (More)
DOI: 10.1007/s00424-017-2106-8

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Cite this paper

@article{Dnnes2017Phosphodiesterase3E, title={Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase}, author={Sarah D{\"u}nnes and Barbara Voussen and Annemarie Aue and Kaja Groneberg and Viacheslav Nikolaev and Dieter Groneberg and Andreas Friebe}, journal={Pfl{\"u}gers Archiv - European Journal of Physiology}, year={2017}, pages={1-10} }