Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing.

@article{KallenbornGerhardt2014Phosphodiesterase2L,
  title={Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing.},
  author={Wiebke Kallenborn-Gerhardt and Ruirui Lu and Aaron Bothe and Dominique Thomas and Jessica Schlaudraff and Jana E Lorenz and Nancy Lippold and Catherine Isabell Real and Nerea Ferreir{\'o}s and Gerd 7 Geisslinger and Domenico Del Turco and Achim Schmidtko},
  journal={Anesthesiology},
  year={2014},
  volume={121 2},
  pages={372-82}
}
BACKGROUND Phosphodiesterase 2A (PDE2A) is an evolutionarily conserved enzyme that catalyzes the degradation of the cyclic nucleotides, cyclic adenosine monophosphate, and/or cyclic guanosine monophosphate. Recent studies reported the expression of PDE2A in the dorsal horn of the spinal cord, pointing to a potential contribution to the processing of pain. However, the functions of PDE2A in spinal pain processing in vivo remained elusive. METHODS Immunohistochemistry, laser microdissection… CONTINUE READING