Phosphodiesterase 11: a brief review of structure, expression and function

  title={Phosphodiesterase 11: a brief review of structure, expression and function},
  author={Antoine Makhlouf and Ashwini Kshirsagar and Craig Niederberger},
  journal={International Journal of Impotence Research},
Phosphodiesterase 11 (PDE11) is the latest isoform of the phosphodiesterase family to be identified. Interest in PDE11 has increased recently because tadalafil, an oral phosphodiesterase 5 inhibitor, cross reacts with PDE11. The function of PDE11 remains largely unknown, but growing evidence points to a possible role in male reproduction. The published literature on PDE11 structure, function and expression is reviewed. 

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