Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease.

@article{Giamp2009Phosphodiesterase1I,
  title={Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease.},
  author={Carmela Giamp{\`a} and Stefano Patassini and Antonella Borreca and Daunia Laurenti and Fabrizia Marullo and Giorgio Bernardi and Frank S. Menniti and Francesca R Fusco},
  journal={Neurobiology of disease},
  year={2009},
  volume={34 3},
  pages={450-6}
}
Decreased activity of cAMP responsive element-binding protein (CREB) is thought to contribute to the death of striatal medium spiny neurons in Huntington's disease (HD). Therefore, therapies that increase levels of activated CREB, may be effective in fighting neurodegeneration in HD. In this study, we sought to determine whether the phosphodiesterase type 10 (PDE10A) inhibitor TP10 exerts a neuroprotective effect in an excitotoxic model of HD. Rats were surgically administered with quinolinic… CONTINUE READING