Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

@article{Shepperd2012PhosphodependentRO,
  title={Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint},
  author={Lindsey A. Shepperd and John C Meadows and Alicja M. Sochaj and Theresa C. Lancaster and Juan Zou and Graham J. Buttrick and Juri Rappsilber and Kevin G Hardwick and Jonathan B A Millar},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={891-899}
}
The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that sister chromatids do not separate until all chromosomes are correctly bioriented during mitosis. Components of the checkpoint include Mad1, Mad2, Mad3 (BubR1), Bub3, and the kinases Bub1, Mph1 (Mps1), and Aurora B. Checkpoint proteins are recruited to kinetochores when individual kinetochores are not bound to spindle microtubules or not under tension. Kinetochore association of Mad2 causes it to undergo a… CONTINUE READING
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Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1.

Proceedings of the National Academy of Sciences of the United States of America • 2012
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