Phosphocreatine pathway for energy transport: ADP diffusion and cardiomyopathy.

@article{Saks1991PhosphocreatinePF,
  title={Phosphocreatine pathway for energy transport: ADP diffusion and cardiomyopathy.},
  author={V. Saks and Yulia Belikova and Andrey V. Kuznetsov and Zaza Khuchua and T. H. Branishte and M. L. Semenovsky and Vladimir Naumov},
  journal={The American journal of physiology},
  year={1991},
  volume={261 4 Suppl},
  pages={
          30-8
        }
}
Chemically skinned (by treatment with saponin, 40 micrograms/ml) isolated cardiomyocytes were used to study the intracellular diffusion of ADP and creatine (Cr). Stimulation of respiration was studied in these cardiomyocytes without intact sarcolemma and in isolated heart mitochondrial by addition of ADP and Cr in the presence of 0.2 mM ATP (via mitochondrial creatine kinase reaction: Cr + MgATP = MgADP + PCr). The Michaelis constant (Km) for Cr was similar in both cases, 5.67 +/- 0.11 (SD) mM… CONTINUE READING

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