Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.

@article{Zhao2009PhosphoaspirinA,
  title={Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.},
  author={Wenping Zhao and Gerardo G Mackenzie and Onika T Murray and Zhiquan Zhang and Basil Rigas},
  journal={Carcinogenesis},
  year={2009},
  volume={30 3},
  pages={
          512-9
        }
}
Aspirin is chemopreventive against colon and probably other cancers, but this effect is relatively weak and its chronic administration to humans is associated with significant side effects. Because of these limitations, extensive effort has been exerted to improve the pharmacological properties of aspirin. We have determined the anticancer activity and mechanisms of action of the novel para positional isomer of phosphoaspirin [P-ASA; MDC-43; 4-((diethoxyphosphoryloxy)methyl)phenyl 2… CONTINUE READING

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