Phosphoaminoglycosides inhibit SWI2/SNF2 family DNA-dependent molecular motor domains.

  title={Phosphoaminoglycosides inhibit SWI2/SNF2 family DNA-dependent molecular motor domains.},
  author={Rohini Muthuswami and Larry D. Mesner and Debao Wang and David A Hill and Anthony N. Imbalzano and Joel W. Hockensmith},
  volume={39 15},
Members of the SWI2/SNF2 family of proteins participate in an array of nucleic acid metabolic functions, including chromatin remodeling and transcription. The present studies identify a novel strategy to specifically inhibit the functional DNA-dependent adenosinetriphosphatase (ATPase) motor domain common to SWI2/SNF2 family members. We have identified preparations of phosphoaminoglycosides, which are natural products of aminoglycoside-resistant bacteria, as inhibitors of the in vitro… CONTINUE READING