Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation.

@article{Clayton2000PhosphoacetylationOH,
  title={Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation.},
  author={Alison L Clayton and Simon A Rose and Michael J. Barratt and Louis C. Mahadevan},
  journal={The EMBO journal},
  year={2000},
  volume={19 14},
  pages={3714-26}
}
The induction of immediate-early (IE) genes, including proto-oncogenes c-fos and c-jun, correlates well with a nucleosomal response, the phosphorylation of histone H3 and HMG-14 mediated via extracellular signal regulated kinase or p38 MAP kinase cascades. Phosphorylation is targeted to a minute fraction of histone H3, which is also especially susceptible to hyperacetylation. Here, we provide direct evidence that phosphorylation and acetylation of histone H3 occur on the same histone H3 tail on… CONTINUE READING

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