Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.

@article{Mackenzie2010PhosphosulindacA,
  title={Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.},
  author={G. Mackenzie and Y. Sun and Liqun Huang and G. Xie and N. Ouyang and Ramesh C. Gupta and F. Johnson and D. Komninou and L. Kopelovich and B. Rigas},
  journal={Gastroenterology},
  year={2010},
  volume={139 4},
  pages={
          1320-32
        }
}
BACKGROUND & AIMS Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective cancer chemopreventive agents. However, chronic administration of NSAIDs is associated with significant side effects, mainly of the gastrointestinal tract. Given these limitations, we synthesized phospho-sulindac (P-S; OXT-328), a novel sulindac derivative. METHODS Here, we evaluated the safety and efficacy of P-S in preclinical models, including its mechanism of action with human colon cancer cell (HCCC) lines and… Expand
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