Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast

@inproceedings{Inada2016PhosphositeMO,
  title={Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast},
  author={Maki Inada and Robert J. Nichols and J R Parsa and Christina M. Homer and Ruby A. Benn and Reyal S. Hoxie and Hiten D Madhani and Stewart Shuman and Beate Schwer and Jeffrey A. Pleiss},
  booktitle={Nucleic acids research},
  year={2016}
}
Eukaryotic gene expression requires that RNA Polymerase II (RNAP II) gain access to DNA in the context of chromatin. The C-terminal domain (CTD) of RNAP II recruits chromatin modifying enzymes to promoters, allowing for transcription initiation or repression. Specific CTD phosphorylation marks facilitate recruitment of chromatin modifiers, transcriptional regulators, and RNA processing factors during the transcription cycle. However, the readable code for recruiting such factors is still not… CONTINUE READING