Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

  title={Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction},
  author={Laurence H. Arnold and Harriet C. T. Groom and Simone Kunzelmann and David Schwefel and Sarah J. Caswell and Paula Ordonez and Melanie C. Mann and Sabrina Rueschenbaum and David C Goldstone and Simon Pennell and Steven A. Howell and Jonathan P Stoye and Michelle Webb and Ian A Taylor and Kate N Bishop and Thomas J Hope},
  booktitle={PLoS pathogens},
SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been proposed recently. Here, we present combined structural and virological data demonstrating that in addition to allosteric activation and triphosphohydrolase activity, restriction correlates with the… CONTINUE READING
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