Phosphine-catalyzed domino reactions: a route to functionalized bicyclic skeletons.

@article{Li2014PhosphinecatalyzedDR,
  title={Phosphine-catalyzed domino reactions: a route to functionalized bicyclic skeletons.},
  author={Erqing Li and You Huang},
  journal={Chemistry},
  year={2014},
  volume={20 12},
  pages={3520-7}
}
A novel strategy that involves phosphine-catalyzed sequential [2+3] and [3+2] annulation reactions was developed. In this domino reaction, γ-substituted allenoates were used as novel C4 synthons, and the bicyclic cyclopenta[b]dihydrofuran derivatives were produced in good to excellent diastereoselectivities and yields under mild conditions. Furthermore, preliminary studies on an asymmetric variant of this reaction proceeded with moderate enantioselectivity. 

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