Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

@article{Filseck2015PhosphatidylserineTB,
  title={Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate},
  author={Joachim Moser von Filseck and Alenka {\vC}opi{\vc} and Vanessa Delfosse and Stefano Vanni and Catherine L Jackson and William Bourguet and Guillaume Drin},
  journal={Science},
  year={2015},
  volume={349},
  pages={432-436}
}
In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter Osh6p extracted phosphatidylinositol 4-phosphate (PI4P) and exchanged PS for PI4P between two membranes. We solved the crystal structure of Osh6p… CONTINUE READING
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