Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans.

@article{Chen2010PhosphatidylserineSA,
  title={Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans.},
  author={Ying-Lien Chen and Anthony E Montedonico and Sarah J. Kauffman and John R. Dunlap and Fu-min Menn and Todd B Reynolds},
  journal={Molecular microbiology},
  year={2010},
  volume={75 5},
  pages={1112-32}
}
Phospholipid biosynthetic pathways play crucial roles in the virulence of several pathogens; however, little is known about how phospholipid synthesis affects pathogenesis in fungi such as Candida albicans. A C. albicans phosphatidylserine (PS) synthase mutant, cho1 Delta/Delta, lacks PS, has decreased phosphatidylethanolamine (PE), and is avirulent in a mouse model of systemic candidiasis. The cho1 Delta/Delta mutant exhibits defects in cell wall integrity, mitochondrial function, filamentous… CONTINUE READING

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