Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish.

@article{Hong2004PhosphatidylserineRI,
  title={Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish.},
  author={J R Hong and Gen-Hwa Lin and Cliff Ji-Fan Lin and W Wang and Chien-chung Lee and T Lin and Jen-Leih Wu},
  journal={Development},
  year={2004},
  volume={131 21},
  pages={5417-27}
}
During development, the role of the phosphatidylserine receptor (PSR) in the removal of apoptotic cells that have died is poorly understood. We have investigated this role of PSR in developing zebrafish. Programmed cell death began during the shield stage, with dead cells being engulfed by a neighboring cell that showed a normal-looking nucleus and the nuclear condensation multi-micronuclei of an apoptotic cell. The zebrafish PSR engulfing receptor was cloned (zfpsr), and its nucleotide… CONTINUE READING
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