Phosphatidylserine is a critical modulator for Akt activation

@inproceedings{Huang2011PhosphatidylserineIA,
  title={Phosphatidylserine is a critical modulator for Akt activation},
  author={Bill X. Huang and Mohammed Akbar and Karl Kevala and Hee-Yong Kim},
  booktitle={The Journal of cell biology},
  year={2011}
}
Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). The extent of insulin-like growth factor-induced Akt activation and downstream signaling as well as cell survival under serum starvation conditions positively correlates with plasma membrane PS levels in living cells. PS promotes Akt-PIP(3) binding, participates in PIP(3… CONTINUE READING

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