Phosphatidylserine induces apoptosis in adherent cells

@article{Iguchi2001PhosphatidylserineIA,
  title={Phosphatidylserine induces apoptosis in adherent cells},
  author={Kazuhiro Iguchi and Kazuyuki Hirano and Motoharu Hamatake and Ryoji Ishida},
  journal={Apoptosis},
  year={2001},
  volume={6},
  pages={263-268}
}
Phosphatidylserine (PS) is exposed on the outer leaflet of the plasma membrane in apoptotic cell death. However, the roles of PS in apoptotic signaling are still unclear. In this study, we found that exogenous PS, but not other phospholipids, induced cell death in adherent cells, but not in suspension culture. The cell death exhibited typical features of apoptosis such as cell shrinkage, nuclear fragmentation and abnormal chromatin condensation. When PS was added to CHO-K1 cells in monolayer… CONTINUE READING

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