Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity.

@article{Martin1996PhosphatidylserineED,
  title={Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity.},
  author={S J Martin and Debra M Finucane and Gustavo Pessini Amarante-Mendes and Glennys A O'Brien and Douglas R Green},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 46},
  pages={28753-6}
}
Phosphatidylserine (PS), a lipid normally confined to the inner leaflet of the plasma membrane, is exported to the outer plasma membrane leaflet during apoptosis to serve as a trigger for recognition of apoptotic cells by phagocytes. The mechanism of PS export during apoptosis is not known nor is it clear whether the nuclear changes that typify apoptosis contribute in any way to this event. Here, we demonstrate that ligation of the CD95 (Fas/APO-1) molecule on Jurkat cytoplasts induces dramatic… CONTINUE READING

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