Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

@article{Yoshida2005PhosphatidylserinedependentEB,
  title={Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells},
  author={Hideyuki Yoshida and Kohki Kawane and Masato Koike and Yoshimi Mori and Yasuo Uchiyama and Shigekazu Nagata},
  journal={Nature},
  year={2005},
  volume={437},
  pages={754-758}
}
Definitive erythropoiesis usually occurs in the bone marrow or fetal liver, where erythroblasts are associated with a central macrophage in anatomical units called ‘blood islands’. Late in erythropoiesis, nuclei are expelled from the erythroid precursor cells and engulfed by the macrophages in the blood island. Here we show that the nuclei are engulfed by macrophages only after they are disconnected from reticulocytes, and that phosphatidylserine, which is often used as an ‘eat me’ signal for… CONTINUE READING

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ErythroblastsAnatomic structure is physical part ofBone Marrow
Definitive erythropoiesis usually occurs in the bone marrow or fetal liver , where erythroblasts are associated with a central macrophage in anatomical units called ‘
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