Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo

@article{Konduru2009PhosphatidylserineTS,
  title={Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo},
  author={Nagarjun V. Konduru and Yulia Y. Tyurina and Weihong Feng and Liana V. Basova and Natalia A. Belikova and H{\"u}lya Bayir and Katherine R. Clark and Marc Rubin and Donna B Stolz and Helen Vallhov and A Scheynius and Erika Witasp and Bengt Fadeel and Padmakar D. Kichambare and Alexander Star and Elena R. Kisin and Ashley R. Murray and Anna A. Shvedova and Valerian E Kagan},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={169 - 182}
}
Broad applications of single-walled carbon nanotubes (SWCNT) dictate the necessity to better understand their health effects. Poor recognition of non-functionalized SWCNT by phagocytes is prohibitive towards controlling their biological action. We report that SWCNT coating with a phospholipid "eat-me" signal, phosphatidylserine (PS), makes them recognizable in vitro by different phagocytic cells - murine RAW264.7 macrophages, primary monocyte-derived human macrophages, dendritic cells, and rat… CONTINUE READING

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