Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells

@article{Li2003PhosphatidylserineRI,
  title={Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells},
  author={Ming O. Li and Matthew R Sarkisian and Wajahat Zafar Mehal and Pasko Rakic and Richard A. Flavell},
  journal={Science},
  year={2003},
  volume={302},
  pages={1560 - 1563}
}
Cells undergoing apoptosis during development are removed by phagocytes, but the underlying mechanisms of this process are not fully understood. Phagocytes lacking the phosphatidylserine receptor (PSR) were defective in removing apoptotic cells. Consequently, in PSR-deficient mice, dead cells accumulated in the lung and brain, causing abnormal development and leading to neonatal lethality. A fraction of PSR knockout mice manifested a hyperplasic brain phenotype resembling that of mice deficient… 

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References

SHOWING 1-10 OF 29 REFERENCES

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl

TLDR
It is shown that PS externalization is an early and widespread event during apoptosis of a variety of murine and human cell types, regardless of the initiating stimulus, and precedes several other events normally associated with this mode of cell death.

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

TLDR
CPP32 is shown to play a critical role during morphogenetic cell death in the mammalian brain during embryonic day 12, resulting in a variety of hyperplasias and disorganized cell deployment.

The phagocytosis of apoptotic cells.

TLDR
The combined investigation of nematode and mammalian models has allowed, in recent years, a fast progression in the field; however, effort is still required to dissect thoroughly the molecular rules orchestrating engulfment.

Phagocytosis and clearance of apoptotic cells is mediated by MER

TLDR
The Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells, which has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus.

Identification of a factor that links apoptotic cells to phagocytes

TLDR
Results indicate that milk fat globule-EGF-factor 8 secreted from activated macrophages binds to apoptotic cells, and brings them to phagocytes for engulfment.