Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells

@article{Li2003PhosphatidylserineRI,
  title={Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells},
  author={Ming O. Li and Matthew R Sarkisian and Wajahat Zafar Mehal and Pasko Rakic and Richard A. Flavell},
  journal={Science},
  year={2003},
  volume={302},
  pages={1560 - 1563}
}
Cells undergoing apoptosis during development are removed by phagocytes, but the underlying mechanisms of this process are not fully understood. Phagocytes lacking the phosphatidylserine receptor (PSR) were defective in removing apoptotic cells. Consequently, in PSR-deficient mice, dead cells accumulated in the lung and brain, causing abnormal development and leading to neonatal lethality. A fraction of PSR knockout mice manifested a hyperplasic brain phenotype resembling that of mice deficient… Expand
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