Corpus ID: 35679374

Phosphatidylserine; Membrane Nutrient for Memory. A Clinical and Mechanistic Assessment

  title={Phosphatidylserine; Membrane Nutrient for Memory. A Clinical and Mechanistic Assessment},
  author={Parris M. Kidd},
Working in the cell membrane milieu, phosphatidylserine (PS) is a nutrient that supports membrane proteins crucial for homeostasis, maintenance, and specialized cell functions. PS is found most concentrated in the brain, where its relative abundance reflects its involvement in specialized nerve cell functions such as chemical transmitter production and release, receptor action, and synaptic activity. The fundamental contributions of PS to the structure and function of individual nerve cells are… Expand

Figures and Tables from this paper

Phosphatidylserine. Monograph.
  • Medicine
  • Alternative medicine review : a journal of clinical therapeutic
  • 2008
Oral supplementation of PS has been shown to affect neuronal membranes, cell metabolism, and specific neurotransmitter systems, including acetylcholine, norepinephrine, serotonin, and dopamine, which exerts significant benefit for cognition. Expand
Phosphatidylserine (PS) as a potential nutraceutical for canine brain aging: A review
Abstract Neurodegenerative processes are one of the main age-related features of dogs. Senile neurodegeneration can be clinically asymptomatic, "borderline" (i.e., a condition that is intermediateExpand
Phosphatidylserine Increases IKBKAP Levels in Familial Dysautonomia Cells
It is shown that phosphatidylserine (PS), an FDA-approved food supplement, increased IKAP mRNA levels in cells derived from FD patients, suggesting that PS has potential for use as a therapeutic agent for FD. Expand
Cell Membranes, Endothelia, and Atherosclerosis - The Importance of Dietary Fatty Acid Balance
For consistent, effective nutritional support against atherosclerosis, a diversified intake of fatty acids should only be undertaken in conjunction with a generous intake of antioxidants. Expand
Nicotinamide loaded functionalized solid lipid nanoparticles improves cognition in Alzheimer’s disease animal model by reducing Tau hyperphosphorylation
Loaded with nicotinamide, an HDAC inhibitor, it could ameliorate the cognition impairment of rats more effectively than the conventional administration of nicotinamide, i.e. oral, in the early stage of Alzheimer’s disease. Expand
A unique antioxidant activity of phosphatidylserine on iron-induced lipid peroxidation of phospholipid bilayers
It is likely that these three acidic phospholipids possess a significant iron-binding ability, although this ability per se does not warrant them antioxidative activities. Expand
A randomized controlled trial investigating the neurocognitive effects of Lacprodan® PL-20, a phospholipid-rich milk protein concentrate, in elderly participants with age-associated memory impairment: The Phospholipid Intervention for Cognitive Ageing Rev
Background: Age-related cognitive decline (ARCD) is of major societal concern in an ageing population, with the development of dietary supplements providing a promising avenue for amelioration ofExpand
A randomized controlled trial investigating the neurocognitive effects of Lacprodan® PL-20, a phospholipid-rich milk protein concentrate, in elderly participants with age-associated memory impairment: the Phospholipid Intervention for Cognitive Ageing Reversal (PLICAR): study protocol for a randomiz
Evaluation of the efficacy of milk-derived phospholipids for AAMI and their mechanisms of action is evaluated to reduce the effects of age-associated memory impairment. Expand
Effect of cold stress on the MAPK pathway and lipidomics on muscle of Takifugu fasciatus
Results showed that T. fasciatus may adjust fat metabolism through MAPK to compensate for cell membrane damage in muscles caused by low temperature, and the possibility that phospholipid metabolites can be used as potential feeds is revealed. Expand
Combinatory Evaluation of Transcriptome and Metabolome Profiles of Low Temperature-induced Resistant Ascites Syndrome in Broiler Chickens
The combinatory evaluation of the metabolome and the transcriptome suggests the possible involvement of glycerophospholipid metabolism in the development of resistant-AS in broilers. Expand


Therapeutic Properties of Phosphatidylserine in the Aging Brain
The structural and regulatory function of phospholipids in biological membranes has stimulated investigation on the pharmacological properties of these compounds, particularly at cerebral level. InExpand
The Therapeutic Value of Phosphatidylserine Effect in the Aging Brain
As the elucidation of the biological roles of membrane phospholipids has progressed, a new field of investigation dealing with the pharmacological effects of these compounds has become possibleExpand
Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.
Physical stress induced a clear-cut increase in plasma E, NE, ACTH, cortisol, GH and PRL, whereas no significant change was observed in plasma DA and glucose, and Pretreatment with both 50 and 75 mg BC-PS significantly blunted the ACTH and cortisol responses to physical stress. Expand
Phosphatidylserine increases hippocampal synaptic efficacy
The increase in hippocampal synaptic efficacy produced by BC-PS is discussed in terms of N-methyl-D-aspartate receptors (NMDA) and the associated channels. Expand
Mechanism of activation of protein kinase C: roles of diolein and phosphatidylserine.
The results suggest that the observed apparent cooperativity is due, at least in part, to the change in dimensionality when PKC binds to the membrane. Expand
Role of phosphatidylserine in membrane actions of tumor necrosis factor and interferons alpha and gamma.
It is suggested that membrane PS modulates the membrane actions ofThese three cytokines, and the possible role of PS in the cytotoxic actions of these cytokines on tumor cells is discussed. Expand
GABA and phosphatidylserine in human photosensitivity: a pilot study
The results indicate that a single acute administration of GABA-PS has no effect in the human photosensitivity model, and suggest that the efficacy of GABA-PS in human epilepsy, as shown by a preliminary investigation, may possibly require chronic administration. Expand
Effects of phosphatidylserine therapy in geriatric patients with depressive disorders
BC‐PS induced consistent improvement of depressive symptoms, memory and behaviour and no changes in amine metabolite levels or in hormonal responses to α2‐adrenoceptor stimulation were observed. Expand
Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease. A neuropsychological, EEG, and PET investigation.
It is indicated that phosphatidylserine treatment has an effect on different measures of brain function and was overcome by the progressive pathological changes at the end of the treatment period. Expand
Exposure of phosphatidylserine in the outer leaflet of human red blood cells. Relationship to cell density, cell age, and clearance by mononuclear cells.
The data suggest that cell age is related to cell density and that cells of increasing age and density display higher amounts of PS in their outer leaflet. Expand