Phosphatidylinositol transfer proteins and instructive regulation of lipid kinase biology.

  title={Phosphatidylinositol transfer proteins and instructive regulation of lipid kinase biology.},
  author={Aby Grabon and Danish Khan and Vytas A Bankaitis},
  journal={Biochimica et biophysica acta},
  volume={1851 6},
Phosphatidylinositol is a metabolic precursor of phosphoinositides and soluble inositol phosphates. Both sets of molecules represent versatile intracellular chemical signals in eukaryotes. While much effort has been invested in understanding the enzymes that produce and consume these molecules, central aspects for how phosphoinositide production is controlled and functionally partitioned remain unresolved and largely unappreciated. It is in this regard that phosphatidylinositol (PtdIns… CONTINUE READING


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