Phosphatidylinositol transfer proteins: the long and winding road to physiological function.

@article{Kearns1998PhosphatidylinositolTP,
  title={Phosphatidylinositol transfer proteins: the long and winding road to physiological function.},
  author={Brian G. Kearns and James G. Alb and Vytas A Bankaitis},
  journal={Trends in cell biology},
  year={1998},
  volume={8 7},
  pages={276-82}
}
Phosphatidylinositol transfer proteins (PITPs) have historically been thought to help execute lipid-sorting events by transporting phospholipid monomers between membrane bilayers. Recent data, however, indicate unanticipated roles for PITPs in the coordination and/or coupling of phospholipid metabolism with vesicle trafficking and the downregulation of signal-transduction reactions. We are only now beginning to appreciate both the identities of PITP-dependent cellular reactions and the… CONTINUE READING

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