Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei.

  title={Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei.},
  author={Kirstee L. Martin and Terry K. Smith},
  journal={The Biochemical journal},
  volume={396 2},
PI (phosphatidylinositol) is a ubiquitous eukaryotic phospholipid which serves as a precursor for messenger molecules and GPI (glycosylphosphatidylinositol) anchors. PI is synthesized either de novo or by head group exchange by a PIS (PI synthase). The synthesis of GPI anchors has previously been validated both genetically and chemically as a drug target in Trypanosoma brucei, the causative parasite of African sleeping sickness. However, nothing is known about the synthesis of PI in this… CONTINUE READING
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