Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen.

@article{Ulug1990PhosphatidylinositolMI,
  title={Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen.},
  author={Emin T. Ulug and Phillip T. Hawkins and Michael R. Hanley and Sara A Courtneidge},
  journal={Journal of virology},
  year={1990},
  volume={64 8},
  pages={
          3895-904
        }
}
  • Emin T. Ulug, Phillip T. Hawkins, +1 author Sara A Courtneidge
  • Published in Journal of virology 1990
  • Biology, Medicine
  • Associated with the middle T antigen of polyomavirus is a novel phosphatidylinositol (PtdIns) kinase activity which phosphorylates PtdIns at the D-3 position of the inositol ring. We have undertaken an analysis of myo-[3H]inositol-containing compounds in a panel of NIH 3T3 cell lines stably transfected with transforming and nontransforming middle T antigen mutants. All cell lines from which PtdIns 3-kinase activity coprecipitated with middle T antigen exhibited modestly elevated levels of… CONTINUE READING

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