Phosphatidylinositol hydrolysis by Trypanosoma brucei glycosylphosphatidylinositol phospholipase C.

@article{Btikofer1996PhosphatidylinositolHB,
  title={Phosphatidylinositol hydrolysis by Trypanosoma brucei glycosylphosphatidylinositol phospholipase C.},
  author={Peter B{\"u}tikofer and Monika Boschung and Urs Brodbeck and Anant K. Menon},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 26},
  pages={15533-41}
}
Detergent-solubilized glycosylphosphatidylinositol (GPI)-anchored structures can be cleaved by C-type phospholipases isolated from peanuts and bloodstream cells of the African trypanosome, Trypanosoma brucei. The two enzymes differ in their reported ability to hydrolyze phosphatidylinositol (PI); while the peanut enzyme readily hydrolyzes PI in vitro, the T. brucei enzyme was reported to be virtually inactive against PI and consequently named GPI-specific phospholipase C (GPI-PLC). In this… CONTINUE READING
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