Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex

@article{Rando2002PhosphatidylinositoldependentAF,
  title={Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex},
  author={O. Rando and K. Zhao and P. Janmey and G. Crabtree},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99},
  pages={2824 - 2829}
}
  • O. Rando, K. Zhao, +1 author G. Crabtree
  • Published 2002
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Recently, several chromatin remodeling complexes in yeast, Drosophila, and mammals have been shown to contain actin and actin-related proteins (arps). However, the function of actin in these complexes is unclear. Here, we show that the mammalian SWI/SNF-like BAF complex binds to phosphatidylinositol 4,5-bisphosphate (PIP2) micelles and PIP2-containing mixed lipid vesicles, and that PIP2 binding allows the complex to associate with actin pointed ends and branch points. Actin binds to at least… CONTINUE READING
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