Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.

  title={Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.},
  author={Oliver J Rando and Keji Zhao and Paul A. Janmey and Gerald R Crabtree},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 5},
Recently, several chromatin remodeling complexes in yeast, Drosophila, and mammals have been shown to contain actin and actin-related proteins (arps). However, the function of actin in these complexes is unclear. Here, we show that the mammalian SWI/SNF-like BAF complex binds to phosphatidylinositol 4,5-bisphosphate (PIP2) micelles and PIP2-containing mixed lipid vesicles, and that PIP2 binding allows the complex to associate with actin pointed ends and branch points. Actin binds to at least… CONTINUE READING
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Nature (London) 385, 265–269

  • M. D. Welch, A. Iwamatsu, T. J. Mitchison
  • Rando et al. PNAS March
  • 1997

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