Phosphatidylinositol Phosphate Kinases Put PI4,5P2 in Its Place

  title={Phosphatidylinositol Phosphate Kinases Put PI4,5P2 in Its Place},
  author={Renee L. Doughman and Ari J Firestone and Richard A. Anderson},
  journal={The Journal of Membrane Biology},
Phosphatidylinositol 4,5 bisphosphate (PI4,5P2) is a critical second messenger that regulates a myriad of diverse cellular activities including modulation of the actin cytoskeleton, vesicle trafficking, focal adhesion formation, and nuclear events. In order to effectively regulate these disparate cellular events, synthesis of PI4,5P2 by phosphatidylinositol phosphate kinases (PIP kinases) must be both spatially and temporally regulated. Two subfamilies of PIP kinases, types I and II, allow the… CONTINUE READING
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