Phosphatidylinositol Glycan ( PIG ) Anchored Membrane Proteins

@inproceedings{Gerber2001PhosphatidylinositolG,
  title={Phosphatidylinositol Glycan ( PIG ) Anchored Membrane Proteins},
  author={Louise Diekmann Gerber and Krishna Kodukula and Sidney UdenfriendS},
  year={2001}
}
Secreted proteins are processed from a nascent form that contains an NHz-terminal signal peptide. During processing, the latter is cleaved by a specific NH2terminal signal peptidase. The nascent form of phosphatidylinositol glycan (PI-G) tailed proteins contain both an NH,and a COOH-terminal signal peptide. The two signal peptides have much in common, such as size and hydrophobicity. The COOH-terminal peptide is also cleaved during processing. We propose that the amino acid in a nascent protein… CONTINUE READING

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