Phosphatidylinositol 5 phosphate 4-kinase regulates insulin sensitivity and PIP3 turnover in Drosophila.

@article{Sharma2018Phosphatidylinositol5P,
  title={Phosphatidylinositol 5 phosphate 4-kinase regulates insulin sensitivity and PIP3 turnover in Drosophila.},
  author={Sanjeev Sharma and Swarna Mathre and Ramya Visvanathan and Dhananjay Shinde and P. Raghu},
  journal={bioRxiv},
  year={2018},
  pages={333153}
}
Phosphatidylinositol-3,4,5-trisphosphate (PIP 3 ) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor and is critical for normal growth and metabolism. The lipid kinases and phosphatases regulating PIP 3 levels are described but mechanisms that control their activity remains unclear. We report that in Drosophila , phosphatidylinositol 5 phosphate 4-kinase (PIP4K) regulates PIP 3 levels during insulin receptor activation… Expand