Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth.

@article{Ghugtyal2015Phosphatidylinositol4phosphatedep,
  title={Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth.},
  author={Vikram Ghugtyal and Roc{\'i}o Garc{\'i}a-Rodas and Agnese Seminara and S{\'e}bastien Schaub and Martine Bassilana and Robert A Arkowitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 28},
  pages={
          8644-9
        }
}
The phospholipid phosphatidylinositol-4-phosphate [PI(4)P], generated at the Golgi and plasma membrane, has been implicated in many processes, including membrane traffic, yet its role in cell morphology changes, such as the budding to filamentous growth transition, is unknown. We show that Golgi PI(4)P is required for such a transition in the human pathogenic fungus Candida albicans. Quantitative analyses of membrane traffic revealed that PI(4)P is required for late Golgi and secretory vesicle… CONTINUE READING
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