Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms.

@article{AltanBonnet2012Phosphatidylinositol4H,
  title={Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms.},
  author={Nihal Altan-Bonnet and Tamas Balla},
  journal={Trends in biochemical sciences},
  year={2012},
  volume={37 7},
  pages={293-302}
}
Several RNA viruses have recently been shown to hijack members of the host phosphatidylinositol (PtdIns) 4-kinase (PI4K) family of enzymes. They use PI4K to generate membranes enriched in phosphatidylinositide 4-phosphate (PtdIns4P or PI4P) lipids, which can be used as replication platforms. Viral replication machinery is assembled on these platforms as a supramolecular complex and PtdIns4P lipids regulate viral RNA synthesis. This article highlights these recent studies on the regulation of… CONTINUE READING