Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi.

@article{Tth2006Phosphatidylinositol4I,
  title={Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi.},
  author={Bal{\'a}zs T{\'o}th and Andr{\'a}s Balla and Hui Ma and Zachary A Knight and Kevan M. Shokat and Tamas Balla},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 47},
  pages={36369-77}
}
The recently identified ceramide transfer protein, CERT, is responsible for the bulk of ceramide transport from the endoplasmic reticulum (ER) to the Golgi. CERT has a C-terminal START domain for ceramide binding and an N-terminal pleck-strin homology domain that binds phosphatidylinositol 4-phosphate suggesting that phosphatidylinositol (PI) 4-kinases are involved in the regulation of CERT-mediated ceramide transport. In the present study fluorescent analogues were used to follow the ER to… CONTINUE READING
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  • S. Raychaudhuri, Y. J. Im, J. H. Hurley, W. A. Prinz
  • J. Cell Biol
  • 2006

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