Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes.

@article{Huang2004Phosphatidylinositol45bisphosphateri,
  title={Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes.},
  author={Shaohui Huang and Larry M Lifshitz and Varsha Patki-Kamath and Richard A. Tuft and Kevin E. Fogarty and M. Czech},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 20},
  pages={9102-23}
}
A major regulator of endocytosis and cortical F-actin is thought to be phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] present in plasma membranes. Here we report that in 3T3-L1 adipocytes, clathrin-coated membrane retrieval and dense concentrations of polymerized actin occur in restricted zones of high endocytic activity. Ultrafast-acquisition and superresolution deconvolution microscopy of cultured adipocytes expressing an enhanced green fluorescent protein- or enhanced cyan fluorescent… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3.

American journal of physiology. Endocrinology and metabolism • 2008
View 18 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 75 references

PIP(2) and proteins: interactions, organization, and information flow.

Annual review of biophysics and biomolecular structure • 2002
View 6 Excerpts
Highly Influenced

Visualizing cellular phosphoinositide pools with GFP-fused protein-modules.

Science's STKE : signal transduction knowledge environment • 2002
View 4 Excerpts
Highly Influenced

PI(4,5)P(2) regulation of surface membrane traffic.

Current opinion in cell biology • 2001
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…