Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex.

@article{Crowder2007Phosphatidylinositol4R,
  title={Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preB{\"o}tzinger complex.},
  author={Erin A. Crowder and Margaret S Saha and Ryland W Pace and Honglu Zhang and Glenn D. Prestwich and Christopher A Del Negro},
  journal={The Journal of physiology},
  year={2007},
  volume={582 Pt 3},
  pages={1047-58}
}
Neurons of the preBötzinger complex (preBötC) form local excitatory networks and synchronously discharge bursts of action potentials during the inspiratory phase of respiratory network activity. Synaptic input periodically evokes a Ca(2+)-activated non-specific cation current (I(CAN)) postsynaptically to generate 10-30 mV transient depolarizations, dubbed inspiratory drive potentials, which underlie inspiratory bursts. The molecular identity of I(CAN) and its regulation by intracellular… CONTINUE READING

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