Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation

  title={Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation},
  author={Ioannis E. Michailidis and Radda Rusinova and Anastasios Georgakopoulos and Yibang Chen and Ravi Iyengar and Nikolaos K. Robakis and Diomedes E. Logothetis and Lia Baki},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2 or PIP2] is a direct modulator of a diverse array of proteins in eukaryotic cells. The functional integrity of transmembrane proteins, such as ion channels and transporters, is critically dependent on specific interactions with PIP2 and other phosphoinositides. Here, we report a novel requirement for PIP2 in the activation of the epidermal growth factor receptor (EGFR). Down-regulation of PIP2 levels either via pharmacological inhibition of PI… CONTINUE READING


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