Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells.

@article{Jiang2000Phosphatidylinositol3S,
  title={Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells.},
  author={Bin Jiang and Jenny Z. Zheng and Masahiro Aoki and Peter K. Vogt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 4},
  pages={1749-53}
}
Phosphatidylinositol 3-kinase (PI 3-kinase) is a signaling molecule that controls numerous cellular properties and activities. The oncogene v-p3k is a homolog of the gene coding for the catalytic subunit of PI 3-kinase, p110alpha. P3k induces transformation of cells in culture, formation of hemangiosarcomas in young chickens, and myogenic differentiation in myoblasts. Here, we describe a role of PI 3-kinase in angiogenesis. Overexpression of the v-P3k protein or of cellular PI 3-kinase equipped… CONTINUE READING
209 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 209 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Induction of angiogenesis by RCAS-VEGF. (A) Angiogenesis was assayed in 9-day-old chicken embryos with 15 ml of concentrated RCAS or RCAS-VEGF virus

  • B. H. Jiang, M. Aoki, J. Z. Zheng, J. Li, P. K. Vogt
  • Proc. Natl. Acad. Sci. USA
  • 1999

M Ed Ic a L Sc Ie N Ce S

  • A. Damert, E. Ikeda, W. Risau
  • PNAS u February
  • 1997

Similar Papers

Loading similar papers…